Voriconazole Monitoring in Children with Invasive Fungal Infections
نویسندگان
چکیده
منابع مشابه
Pharmacotherapy of Invasive Fungal Infections with Voriconazole
Voriconazole, a second-generation and broad-spectrum triazole derivative of fluconazole, inhibits the cytochrome P450 (CYP)-dependent enzyme 14-α-sterol demethylase, which is a pivotal step in cell membrane ergosterol synthesis in fungi. CYP2C19, CYP3A4, flavin-containing monooxygenase (FMO), and to a lesser extent CYP2C9 contribute to the oxidative metabolism of voriconazole by human liver mic...
متن کاملInvasive fungal infections in children.
The past two decades have seen a considerable increase in both frequency and importance of opportunistic invasive fungal infections in pediatric hospitals. At the same time, major advances have been made in the diagnosis of fungal diseases, the development of algorithms of antifungal interventions, and the design and implementation of pediatric clinical trials. Most importantly, several new ant...
متن کاملVoriconazole in the management of nosocomial invasive fungal infections
Voriconazole is a new triazole developed for the treatment of life-threatening fungal infections. The drug is available for both oral and intravenous administration; the oral formulation has excellent bioavailability. The side-effect profile of voriconazole presents an acceptable safety and tolerability spectrum: transient visual disturbances, liver enzyme abnormalities, and skin rashes are the...
متن کاملRole of therapeutic drug monitoring of voriconazole in the treatment of invasive fungal infections.
BACKGROUND Voriconazole is a broad-spectrum, second-generation triazole antifungal agent with demonstrated efficacy in the treatment of invasive fungal infections caused by Aspergillus spp. and Candida spp. Given the characteristically poor prognosis of patients with invasive fungal infections and the protracted duration of treatment required, therapeutic monitoring of voriconazole is, in theor...
متن کاملVoriconazole drug monitoring in the management of invasive fungal infection in immunocompromised children: a prospective study.
OBJECTIVES To evaluate voriconazole plasma level monitoring in immunocompromised children and determine the relationship of plasma levels with dose, safety and efficacy. METHODS We used a prospective study including all consecutive children with invasive fungal infection (IFI) treated with voriconazole between August 2008 and May 2010. IFI diagnosis and clinical outcome evaluation were based ...
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ژورنال
عنوان ژورنال: The Journal of Pediatric Pharmacology and Therapeutics
سال: 2015
ISSN: 1551-6776
DOI: 10.5863/1551-6776-20.1.17